Allergy References

*Galli E, Bassi MS, Mora E, Martelli M, Gianni S, Auricchio G, Arabito E, Rossi P.
A double-blind randomized placebo-controlled trial with short-term beta-glucuronidase therapy in children with chronic rhinoconjunctivitis and/or asthma due to dust mite allergy. J Investig Allergol Clin Immunol. 2006; 16(6):345-50. PMID: 17153881 [PubMed – indexed for MEDLINE]
Pulec JL.
Enzyme-potentiated desensitization in otolaryngic allergy. Ear Nose Throat J. 2002 Mar;81(3):164-7.
Troise C, Bignardi D, Modena P, Pissacroia C, Di Berardino F.
Preventive symptomatic immunotherapy versus placebo in seasonal rhinitis due to grasses in children and to Parietaria in adult patients. Allerg Immunol (Paris). 2000 Jun;32(6):246-9.
Ward, WA. Enzyme potentiated desensitization (EPD): a potential revolution in allergy care. Current Opinion in Otolaryngology & Head and Neck Surgery2000, 8:273-276.
Ippoliti F, Ragno V, Del Nero A, McEwen LM, McEwen H, Businco L.
 Effect of preseasonal enzyme potentiated desensitisation (EPD) on plasma-IL-6 and IL-10 of grass pollen-sensitive asthmatic children. Allerg Immunol (Paris). 1997 May;29(5):120, 123-5.
Cantani A, Ragno V, Monteleone MA, Lucenti P, Businco L.
Enzyme-potentiated desensitization in children with asthma and mite allergy: a double-blind study. J Investig Allergol Clin Immunol. 1996 Jul-Aug;6(4):270-6.
Astarita C, Scala G, Sproviero S, Franzese A.
Effects of enzyme-potentiated desensitization in the treatment of pollinosis: a double-blind placebo-controlled trial.
J Investig Allergol Clin Immunol. 1996 Jul-Aug;6(4):248-55.
Egger J, Stolla A, McEwen LM.
Controlled trial of hyposensitisation in children with food-induced hyperkinetic syndrome. Lancet. 1992 May 9;339(8802):1150-3.
McEwen LM. Ganderton MA. Wilson CW. Black JH. Hyaluronidase in the treatment of allergy. British Medical Journal. ii: 507-8, 1967.
McEwen LM. Starr MS. Enzyme potentiated hyposensitization I: The effect of pre-treatment with beta-glucuronidase, hyaluronidase and antigen on anaphylactic sensitivity of guinea pigs, rats and mice. International Archives of Allergy. 42:152-8, 1972.
McEwen LM. Enzyme potentiated hyposensitization II: Effect of glucose, glucosamine, N-acetylamino-sugars and gelatin on the ability of beta- glucuronidase to block the anamnestic response to antigen in mice. Annals of Allergy. 31:79-83,1973.
McEwen LM. Effects of sugars and diols on enzyme potentiated desensitization.Journal of Physiology. 230(1): 65-6, 1973 Apr.
McEwen LM. Nicholson M. Kitchen I. White S. Enzyme potentiated hyposensitization III: Control by sugars and diols of the immunological effect of beta-glucuronidase in mice and patients with hay fever. Annals of Allergy. 31(11), 543-50, 1973.
McEwen LM. Nicholson M. Kitchen I. O’Gorman J. White S. Enzyme potentiated hyposensitization IV: Effect of protamine on the immunological behavior of beta-glucuronidase in mice and patients with hay fever. Annals of Allergy. 34:290-5,1975.
McEwen LM. Enzyme potentiated hyposensitization V: Five case reports of patients with acute food allergy. Annals of Allergy. 35:98-103,1975.
McEwen LM. A double-blind controlled trial of enzyme potentiated hyposensitization for the treatment of ulcerative colitis. Clinical Ecology. 5(2): 47-51, 1987.
McEwen LM. Hyposensitization. In: Brostoff J and Challacombe SJ., Eds. Food allergy and intolerance. London; Bailliere Tindall, 985-94, 1987.
Fell P. Brostoff JA. Single dose desensitization for summer hay fever. European Journal of Clinical Pharmacology. 38: 77-9,1990.
Eaton KK. Preliminary studies with enzyme potentiated desensitization in canine atopic dermatitis. Environmental Medicine. 8:140-1,1991.
Longo G. Poli F. Bertoli G. Efficacia clinica di UN novo trattemento iposensibilizzante, EPD (enzyme potentiated desensitization) nella terapia Della pollinosi. Reforma Medica. 107:171-6,1992.
Eggar J. Stolla A. McEwen LM. Controlled trial of hyposensitization in children with food-induced hyperkinetic syndrome. Lancet. 339:1150-3, 1992 May 9.
Shrader Jr. WA. McEwen LM. Enzyme potentiated desensitization: A sixteen month trial of therapy with 134 patients. Environmental Medicine. 9 (3&4): 128-38, 1993.
Angelini G. Curatoli G. D’Argento V. Vena GA. Pollinosi: una nuova metodica di immunoterapia.Medit. J. Surg. Med., 253-6, 1993
Eggar J. Stolla A. McEwen L.M. Hyposensibilisierung bei nahrungsmittelinduzierter migrane. Actuelle Neuropadiatrie. 1992. A. Lishka, G. Bernett (Eds.) 1992. 287-291. Ciba-Geigy Verlag, Wehr 1993.
Eggar J. Stolla A. McEwen LM. Controlled trial of hyposensitization in children with food induced migraine. Cephalgia.13: Suppl. 216, 1993.
Di Stanislao C. Mazzocchetti E. Bologna G Chimenti S. EPD secondo McEwen: Studio cliniico, istologia e immunoistochimico. Bollentino de dermatologia allergologia e professionale, 2, 1994
Astarita C. et al. Effects of enzyme potentiated desensitization in the treatment of pollinosis: A double-blind placebo-controlled trial. Journal of Investigational Allergology and Clinical Immunology 6(4): 248-255, 1996 July-Aug.
Cantani A. Vanda Ragno V. Monteleone A. Lucenti P. Businco L. Enzyme-potentiated desensitization in children with asthma and mite allergy: A double-blind study. Journal of Investigational Allergology and Clinical Immunology. 6(4): 270-76, 1996 Jul.-Aug.
Galland L. McEwen L.M. A role for food intolerance in childhood migraine. World Ped. & Child Care. 6: 2-8, 1996.
Pulec JL. Enzyme-potentiated desensitization: a major breakthrough [editorial]. Ear, Nose, & Throat Journal. 75(10): 640, 1996 Oct.
Caramia G. Franceschini F. Cimarelli ZA. Ciucchi MS. Gagliardini R. Ruffini E. The efficacy of E.P.D., a new immunotherapy, in the treatment of allergic diseases in children. Allergie et Immunologie. 28(9): 308-10, 1996 Nov.
Ippoliti F. Rivi R. Businco L. Effect of preseasonal enzyme potentiated desensitization (EPD) on plasma IL-6 and IL-10 in grass pollen-sensitive asthmatic children. Allergie et Immunologie; 29(5): 120, 123-25, 1997.
Di Stanislao C. Mazzocchetti E. Bologna G Chimenti S. A double-blind, placebo-controlled study of preventative immunotherapy with EPD in the treatment of seasonal allergic disease. Allergie et immunologie. 29(2): 39-42, 1997.
Ward WA. Enzyme potentiated desensitization (EPD): a potential revolution in allergy care. Current Opinion in Otolaryngology & Head and Neck Surgery. 8:273-6, 2000.
Shrader, Jr. WA. The use of bacterial antigen EPD immunotherapy for the treatment of rheumatoid arthritis and reactive arthritis: the role of molecular mimicry (unpublished), 1996, revised 1998, 2000.
Shrader, W.A., Treating Allergies with EPD Immunotherapy, in Optimal Digestion, Faas, N., 370-78, Harper-Collins, 1999.
Shrader, Jr., W.A. Short and long-term treatment of asthma with intravenous nutrients. Nutr J. May 14 2004; 3(1): 6.